SOLITHROMYCIN INHIBITS IL-13-INDUCED GOBLET CELL HYPERPLASIA AND MUC5AC, CLCA1, AND ANO1 IN HUMAN BRONCHIAL EPITHELIAL CELLS

Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells

Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics.Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription factor (SPDEF), chloride channel accessory 1 (CLCA1), and anoctamin-1 (ANO1), all of which are associa

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P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study.

BackgroundEarly markers to predict delayed kidney graft function (DGF) may support clinical management.We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with e

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Campylobacter jejuni and Campylobacter coli autotransporter genes exhibit lineage-associated distribution and decay

Abstract Background Campylobacter jejuni and Campylobacter Accessories coli are major global causes of bacterial gastroenteritis.Whilst several individual colonisation and virulence factors have been identified, our understanding of their role in the transmission, pathogenesis and ecology of Campylobacter has been hampered by the genotypic and phen

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